Understanding Knee Osteoarthritis

Research suggests that stem cells, specifically mesenchymal stem cells (MSCs), could be a groundbreaking treatment for knee osteoarthritis. These cells play a crucial role in repairing damaged cartilage and regulating inflammation.

Causes of Knee Osteoarthritis

Knee osteoarthritis is caused by the degeneration of articular cartilage, affecting the shape, structure, and function of the joint. The underlying causes include:

• Age: As we age, cells in the body deteriorate, leading to the degeneration of joint cartilage and muscles.
• Genetics: Studies have shown a genetic predisposition to knee osteoarthritis. If there is a family history of this condition, the risk is higher.
• Gender: Women are more prone to knee osteoarthritis, especially after menopause, due to the loss of estrogen, a hormone that protects articular cartilage.
• Weight: Excess weight puts additional stress on the knees and can accelerate cartilage degeneration.
• Overuse: Activities involving heavy lifting or frequent stair climbing can contribute to knee osteoarthritis.
• Injuries and Diseases: Injuries or conditions like rheumatoid arthritis, gout, joint infections, and diseases affecting structures outside the knee can also lead to osteoarthritis.

Symptoms of Knee Osteoarthritis

Initial symptoms include pain when moving the knee, a grinding sensation, and gradually increasing pain. As the condition progresses, symptoms may include pain, swelling, warmth, stiffness, and a bowed or deformed knee, ultimately affecting mobility and daily activities.



Knee Osteoarthritis and UC-MSCs

UC-MSCs (Umbilical Cord Mesenchymal Stem Cells) have shown promise in treating knee osteoarthritis. These cells have the ability to differentiate into various cell types, including cartilage cells, and can help repair and alleviate symptoms of joint degeneration.

Numerous studies have confirmed the benefits of MSCs in treating osteoarthritis. Patients treated with UC-MSCs have reported reduced pain and improved knee function.

Advantages of Stem Cell Therapy for Knee Osteoarthritis

• Minimally Invasive: Stem cell injections are less invasive than traditional surgeries, reducing the risk of complications.
• Faster Recovery: Stem cell therapy allows for quicker recovery compared to surgery.
• Long-Term Pain and Inflammation Reduction: Stem cells have anti-inflammatory properties and can provide long-lasting pain relief.

For those seeking alternatives to pain medication and surgery, stem cell therapy is a promising option. While individual results may vary, the recommended dosage is 15 million cells per treatment to ensure sufficient cell proliferation and differentiation into cartilage cells, aiding in the repair of damaged cartilage.

Knee osteoarthritis is a debilitating condition that can significantly impact quality of life. Stem cell therapy offers a promising and minimally invasive treatment option, providing relief from pain and improving joint function. However, it is essential to consult with a healthcare professional for a personalized treatment plan.

นายแพทย์วิโรจน์ กวินวงศ์โกวิท. (2558).  กระดูกและข้อดูแลได้.  (https://www.rama.mahidol.ac.th/rama_hospital/th/services/knowledge/05272020-1112)

Ye Chen, Rui-Juan Cheng, Yinlan Wu, Deying Huang, Yanhong Li, and Yi Liu. (2024). Advances in Stem Cell-Based Therapies in the Treatment of Osteoarthritis. (https://www.mdpi.com/1422-0067/25/1/394)